Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6795892 | 0.86 | ALDH1A1 (0.53) | KMT2AALDH1A1POLBTDP1KDM4E | |
| SCHEMBL2895893 | 0.77 | ALDH1A1 (0.55) | KMT2AALDH1A1POLBTDP1KDM4E | |
| SCHEMBL6357988 | 0.76 | KDM4E (0.53) | KMT2AALDH1A1POLBTDP1KDM4E | |
| SCHEMBL6363840 | 0.76 | GRIN2B (0.45) | KMT2AALDH1A1GAAMEN1 | |
| SCHEMBL2891323 | 0.73 | KDM4E (0.49) | KMT2AALDH1A1POLBTDP1KDM4E | |
| SCHEMBL18205140 | 0.72 | KDM4E (0.52) | KMT2AALDH1A1POLBTDP1KDM4E | |
| SCHEMBL9804694 | 0.72 | KDM4E (0.61) | KMT2AALDH1A1POLBTDP1KDM4E | |
| SCHEMBL5191004 | 0.72 | TSHR (0.63) | KMT2AALDH1A1POLBTDP1KDM4E | |
| SCHEMBL5242472 | 0.71 | BTK (0.51) | KMT2AALDH1A1POLBTDP1KDM4E | |
| SCHEMBL10906073 | 0.71 | ALDH1A1 (0.51) | KMT2AALDH1A1POLBTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |