Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GLS | O94925 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29672808 | 0.83 | CA1 (0.56) | SMN1; SMN2POLBCA1CA2CA5A | |
| SCHEMBL1032275 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBCA1CA2CA5A | |
| SCHEMBL24015947 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBCA1CA2CA5A | |
| SCHEMBL966286 | 0.83 | CA1 (0.56) | SMN1; SMN2POLBCA1CA2CA5A | |
| Potassium Ion SCHEMBL11394989 | 0.81 | CA1 (0.55) | SMN1; SMN2POLBCA1CA2CA5A | |
| Hydrochloric Acid SCHEMBL11689290 | 0.81 | CA1 (0.55) | SMN1; SMN2POLBCA1CA2CA5A | |
| SCHEMBL2028409 | 0.80 | CA1 (0.69) | SMN1; SMN2POLBCA1CA2CA5A | |
| SCHEMBL5032696 | 0.80 | POLB (0.58) | SMN1; SMN2POLBCA1CA2CA5A | |
| SCHEMBL4579337 | 0.80 | HDAC1 (0.54) | SMN1; SMN2POLBHDAC6HDAC8MEN1 | |
| SCHEMBL2142240 | 0.79 | RAB9A (0.58) | SMN1; SMN2POLBCA1CA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0060144-A2 | Cephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1982-09-15 | — | — | EP | claimed |
| US-6743794-B2 | MULTIDRUG RESISTANCE PROTEIN; CANCER; 3-(9-CHLORO-3-METHYL-4-OXO-5H-ISOXAZOLO(4,3-C)QUINOLIN-5-YL)) CYCLOHEXYL)-2-PIPERIDYLACETAMIDE | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |
| EP-0060144-A2 | Cephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1982-09-15 | — | — | EP | disclosed |
| US-4336253-A | Cephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1982-06-22 | — | — | US | disclosed |