Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855484 | 0.80 | SLC6A2 (0.32) | — | |
| Hydroxyamine SCHEMBL8631067 | 0.79 | SLC6A2 (0.31) | — | |
| SCHEMBL8343053 | 0.77 | BCHE (0.35) | — | |
| SCHEMBL28349985 | 0.73 | SRC (0.33) | — | |
| SCHEMBL27547337 | 0.72 | MEN1 (0.36) | — | |
| SCHEMBL6796408 | 0.71 | — | — | |
| SCHEMBL6855480 | 0.71 | CHRNB4 (0.34) | — | |
| SCHEMBL26604987 | 0.70 | CES2 (0.39) | — | |
| Hydroxyamine SCHEMBL8631065 | 0.69 | SLC6A2 (0.33) | — | |
| Lithium SCHEMBL29904177 | 0.68 | SMN1; SMN2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750344-B1 | MONOCYCLIC AMINE SCAFFOLD BEARING AT LEAST TWO SITES OF DIVERSITY, CYCLIZED TO FORM BICYCLIC AMINE SCAFFOLDS; 7-AMINO-PYRROLO(1,2-A)PYRAZIN-4-ONE COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-6316626-B1 | Amine compounds and combinatorial libraries comprising same | ISIS PHARMACEUTICALS, INC. | 2001-11-13 | — | — | US | disclosed |