Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796586 | 0.83 | HDAC1 (0.46) | SIGMAR1MAOBMAP4K4GRIN2BGPR183 | |
| SCHEMBL1012603 | 0.73 | HDAC3 (0.56) | MAOBMAP4K4GRIN2BCYP2D6HDAC3 | |
| SCHEMBL6797003 | 0.73 | GRIN2B (0.38) | SIGMAR1GRIN2BGPR183DRD2DRD4 | |
| SCHEMBL6363840 | 0.70 | GRIN2B (0.45) | GRIN2B | |
| SCHEMBL17896857 | 0.69 | MAOB (0.52) | MAOBMAP4K4 | |
| SCHEMBL15587429 | 0.69 | MAOB (0.52) | MAOBMAP4K4 | |
| SCHEMBL8242862 | 0.66 | HDAC3 (0.76) | CYP2D6CYP2C19HDAC3HDAC4HDAC1 | |
| SCHEMBL3081900 | 0.66 | GPR183 (0.54) | SIGMAR1GPR183FAAHCYP2D6CYP2C9 | |
| SCHEMBL17896327 | 0.66 | MAOB (0.49) | MAOBMAP4K4 | |
| SCHEMBL13649146 | 0.66 | GRIN2B (0.55) | SIGMAR1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |