Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796586 | 0.76 | HDAC1 (0.46) | GRIN2BDRD2SIGMAR1GPR183DRD4 | |
| SCHEMBL21257972 | 0.74 | KDM4E (0.50) | DRD2SIGMAR1 | |
| SCHEMBL6796583 | 0.73 | SIGMAR1 (0.39) | GRIN2BDRD2SIGMAR1GPR183DRD4 | |
| SCHEMBL21257992 | 0.73 | KDM4E (0.55) | SIGMAR1 | |
| SCHEMBL21257963 | 0.71 | HRH3 (0.54) | — | |
| SCHEMBL6796714 | 0.70 | GAA (0.41) | GRIN2B | |
| SCHEMBL6797008 | 0.68 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL6804350 | 0.67 | GRIN2B (0.43) | GRIN2B | |
| SCHEMBL21257991 | 0.67 | KMT2A (0.52) | — | |
| SCHEMBL1012603 | 0.67 | HDAC3 (0.56) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |