Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796583 | 0.83 | SIGMAR1 (0.39) | HDAC1HDAC2GRIN2BGPR183DRD2 | |
| SCHEMBL6356897 | 0.79 | HDAC1 (0.47) | HDAC1HDAC2GRIN2BSIGMAR1DPP4 | |
| SCHEMBL6797003 | 0.76 | GRIN2B (0.38) | GRIN2BGPR183DRD2DRD4SIGMAR1 | |
| SCHEMBL1012603 | 0.70 | HDAC3 (0.56) | HDAC1HDAC2GRIN2BCYP2D6MAOB | |
| SCHEMBL6363842 | 0.70 | GRIN2B (0.45) | GRIN2B | |
| SCHEMBL6795892 | 0.67 | ALDH1A1 (0.53) | TSHR | |
| SCHEMBL17598327 | 0.66 | CHRNB2 (0.41) | HDAC1HDAC2SIGMAR1CHRNA4CHRNB2 | |
| SCHEMBL8242862 | 0.66 | HDAC3 (0.76) | HDAC1HDAC2CYP2D6CYP2C19HDAC3 | |
| SCHEMBL3081900 | 0.66 | GPR183 (0.54) | GPR183CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL15587429 | 0.66 | MAOB (0.52) | MAOBMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |