Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.67 |
| ▸ | CCR2 | P41597 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MGLL | Q99685 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HPN | P05981 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10826462 | 0.87 | ALDH1A1 (0.71) | ATMALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL11666343 | 0.85 | CCR2 (0.57) | ATMCCR2ALDH1A1KDM4EMEN1 | |
| SCHEMBL5626457 | 0.84 | ALDH1A1 (0.74) | CCR2ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7311276 | 0.84 | ATM (0.84) | ATMLMNASMN1; SMN2KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL16226937 | 0.83 | ATM (0.82) | ATMLMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4477546 | 0.81 | KDM4E (0.70) | CCR2ALDH1A1LMNAMAPTSMN1; SMN2 | |
| Fumaric Acid SCHEMBL10826546 | 0.81 | ALDH1A1 (0.61) | ATMALDH1A1LMNAMAPTSMN1; SMN2 | |
| Fumaric Acid SCHEMBL10826550 | 0.81 | ALDH1A1 (0.61) | ATMALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL588110 | 0.80 | KCNH2 (0.78) | ATMALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL588111 | 0.80 | KCNH2 (0.78) | ATMALDH1A1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408037-A1 | Novel diarylmethylpiperazine and diarylmethylphenyl compounds with analgesic effect | AstraZeneca AB (SE) | 2004-04-14 | — | — | EP | disclosed |
| US-6680321-B1 | 4-((1-PIPERAZINYLMETHYL)-BENZAMIDE DERIVATIVES; HYPOTENSIVE AGENTS; IMMUNOMODULATORS | ASTRAZENECA CANADA, INC. (CA) | 2004-01-20 | — | — | US | disclosed |
| US-6130222-A | Compounds with analgesic effect | ASTRA PHARMA INC. (CA) | 2000-10-10 | — | — | US | disclosed |
| EP-0915855-A1 | NOVEL COMPOUNDS WITH ANALGESIC EFFECT | Astra Pharma Inc. (CA) | 1999-05-19 | — | — | EP | disclosed |