SCHEMBL679669

SCHEMBL679669

C#Cc1cc(C)c(NC(=O)c2cc(Br)nn2-c2ncccc2Cl)c(C(=O)NC)c1

nearest known ligand 0.82

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.43
MALT1 Q9UDY8 3/20 0.34
NTRK1 P04629 4/20 0.31
GRM4 Q14833 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
GRM1 Q13255 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
RIPK1 Q13546 1/20 0.30
LMNA P02545 1/20 0.30
MTOR P42345 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cyantraniliprole SCHEMBL29354965 0.92 DHODH (0.42) DHODHMALT1KMT2ARIPK1
Cyantraniliprole SCHEMBL166640 0.92 DHODH (0.42) DHODHMALT1KMT2ARIPK1
Chlorantraniliprole SCHEMBL29363261 0.90 DHODH (0.44) DHODHMALT1NTRK1NPC1RAB9A
SCHEMBL30058805 0.90 DHODH (0.44) DHODHMALT1NTRK1GRM4MEN1
SCHEMBL678528 0.90 DHODH (0.44) DHODHMALT1NTRK1GRM4RIPK1
SCHEMBL782370 0.90 DHODH (0.44) DHODHMALT1NTRK1GRM4MEN1
Chlorantraniliprole SCHEMBL29551 0.90 DHODH (0.44) DHODHMALT1NTRK1NPC1RAB9A
SCHEMBL24576222 0.89 DHODH (0.44) DHODHMALT1NTRK1GRM4
SCHEMBL13287802 0.89 DHODH (0.43) DHODHMALT1NTRK1GRM4
SCHEMBL10028767 0.89 DHODH (0.45) DHODHMALT1NTRK1GRM4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140087946-A1 Selective Insecticides Based on Anthranilic Acid Diamides and Safeners BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-03-27 US disclosed
US-20110059991-A1 Selective Insecticides Based on Anthranilic Acid Diamides and Safeners BAYER CROPSCIENCE AG (DE) 2011-03-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140087946-A1 Selective Insecticides Based on Anthranilic Acid Diamides and Safeners DDC, DDT, AADAC DHODH 347/4885MALT1 4492/4885NTRK1 3658/4885
US-20110059991-A1 Selective Insecticides Based on Anthranilic Acid Diamides and Safeners DDC, DDT, AADAC DHODH 347/4885MALT1 4492/4885NTRK1 3658/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.