Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348092 | 0.89 | ABCB1 (0.42) | PREPPOLBHTR2CNPSR1MEN1 | |
| SCHEMBL6803097 | 0.89 | POLB (0.43) | PREPPOLBHTR2CNPSR1MEN1 | |
| SCHEMBL31721849 | 0.83 | POLB (0.43) | PREPPOLBHTR2CNPSR1PSEN1 | |
| SCHEMBL31722127 | 0.82 | POLB (0.55) | PREPPOLBHTR2CNPSR1PSEN1 | |
| SCHEMBL26714275 | 0.82 | POLB (0.55) | PREPPOLBHTR2CNPSR1PSEN1 | |
| SCHEMBL28616119 | 0.82 | POLB (0.46) | PREPPOLBHTR2CNPSR1NPC1 | |
| SCHEMBL6798528 | 0.82 | POLB (0.46) | PREPPOLBHTR2CNPSR1NPC1 | |
| SCHEMBL28611699 | 0.82 | POLB (0.46) | PREPPOLBHTR2CNPSR1NPC1 | |
| SCHEMBL6319947 | 0.80 | POLB (0.45) | PREPPOLBHTR2CNPSR1PSEN1 | |
| SCHEMBL9639974 | 0.80 | ABCB1 (0.41) | PREPPOLBHTR2CNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833456-B2 | Heterocyclic sulfides such as 5-(2-(2R-Hydroxymethyl-pyrrolidine-1-carbonyl)-thieno(3,2-b)pyridin-7 -ylamino)-2-methyl-indole-1-carboxylic acid methylamide, used as angiogenesis inhibitors | AGOURON PHARMACEUTICALS, INC. | 2004-12-21 | — | — | US | disclosed |