Dicentrine

Dicentrine

SCHEMBL679684

COc1cc2c(cc1OC)-c1c3c(cc4c1C(C2)N(C)CC4)OCO3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 1.00
POLB P06746 2/20 1.00
CASP6 P55212 2/20 1.00
KMT2A Q03164 2/20 1.00
LMNA P02545 2/20 1.00
TDP2 O95551 2/20 1.00
MAPT P10636 2/20 1.00
RAD52 P43351 2/20 1.00
BCHE P06276 2/20 0.76
ACHE P22303 2/20 0.76
DRD2 P14416 5/20 0.75
ADRA1A P35348 3/20 0.75
HTR2A P28223 3/20 0.75
HTR2C P28335 3/20 0.75
HTR2B P41595 3/20 0.75
ADRA1D P25100 2/20 0.75
ADRA1B P35368 2/20 0.75
DRD1 P21728 2/20 0.75
HTR7 P34969 2/20 0.75
ADRB1 P08588 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dicentrine SCHEMBL31237199 1.00 KDM4E (1.00) KDM4EPOLBCASP6KMT2ALMNA
Dicentrine SCHEMBL6369440 1.00 KDM4E (1.00) KDM4EPOLBCASP6KMT2ALMNA
Dicentrine SCHEMBL30475130 1.00 KDM4E (1.00) KDM4EPOLBCASP6KMT2ALMNA
Dicentrine SCHEMBL31237335 1.00 KDM4E (1.00) KDM4EPOLBCASP6KMT2ALMNA
Dicentrine SCHEMBL28850766 1.00 KDM4E (1.00) KDM4EPOLBCASP6KMT2ALMNA
Cassythicine SCHEMBL30883018 0.92 KDM4E (0.84) KDM4EPOLBCASP6KMT2ALMNA
Cassythicine SCHEMBL31029807 0.92 KDM4E (0.84) KDM4EPOLBCASP6KMT2ALMNA
Neolitsine SCHEMBL31029789 0.90 POLB (0.81) KDM4EPOLBCASP6KMT2ALMNA
SCHEMBL29751877 0.87 BCHE (0.86) KDM4EPOLBCASP6KMT2ALMNA
SCHEMBL28760154 0.87 BCHE (0.86) KDM4EPOLBCASP6KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 285 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240261252-A1 Methods of use and formulations of allosteric modulators of the serotonin, dopamine and other receptor systems for medical, recreational, religious, research and other uses. HELDRETH JR DAVID ALAN (US) 2024-08-08 US claimed
CN-115137829-A Medicine for relieving radiation therapy-induced intestinal injury 山东大学 2022-10-04 CN claimed
US-20220265601-A1 Methods of use and formulations of allosteric modulators of the serotonin, dopamine and other receptor systems for medical, recreational, religious, research and other uses. Heldreth, JR., David Alan (US) 2022-08-25 US claimed
CN-113975206-A Mouthwash for inhibiting helicobacter pylori and preparation method thereof 江苏罗来雅实业股份有限公司 2022-01-28 CN claimed
CN-109456335-B Method for synthesizing oxidized bicuculline 广西师范大学 2021-07-23 CN claimed
EP-3500271-A1 GENOME EDITING ENHANCERS Bluebird Bio, Inc. (US) 2019-06-26 EP claimed
US-20190169597-A1 GENOME EDITING ENHANCERS BLUEBIRD BIO, INC. (US) 2019-06-06 US claimed
WO-2018035423-A1 GENOME EDITING ENHANCERS BLUEBIRD BIO, INC. (US) 2018-02-22 WO claimed
CN-106226509-A A kind of method in mice anterior cingutate cortex induction DSE phenomenon 中国人民解放军第四军医大学 2016-12-14 CN claimed
CN-105803015-A Method for converting dicentrine into (4S,6aR)-4-hydroxyl dicentrine through Clonostachys sp. Fermentation 云南大学 2016-07-27 CN claimed
CN-1259974-C Drug giving-up medicine made-up by non-thebaica medicines YONG WEICHANG (CN) 2006-06-21 CN claimed
CN-1686390-A Tongkening drip pill used for assistant treating of tumour and its preparation method ZHENGDA LUZHOU MED SCIENCE (CN) 2005-10-26 CN claimed
CN-1655813-A Parakeratosis inhibitor, pore-shrinking agent, and external preparation for skin SHISEIDO CO LTD (JP) 2005-08-17 CN claimed
CN-1579551-A Drug giving-up medicine made-up by non-thebaica medicines YONG WEICHANG (CN) 2005-02-16 CN claimed
CN-1157201-C Composite non-opium medicine for dropping drugs 卢正堂 2004-07-14 CN claimed
CN-1450883-A Transdermal delivery system for alkaloids of aconitum species XEL HERBACEUTICALS (US) 2003-10-22 CN claimed
CN-1313108-A Composite non-opium medicine for dropping drugs LU ZHENGTANG (CN) 2001-09-19 CN claimed
US-5348959-A Alkaloid NATIONAL SCIENCE COUNCIL (TW) 1994-09-20 US claimed
US-5270321-A Use of dicentrine and its derivatives for the treatment of arrhythmia NATIONAL SCIENCE COUNCIL 1993-12-14 US claimed
US-5262421-A ADMINISTERING DICENTRINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS TO PATIENT NATIONAL SCIENCE COUNCIL (TW) 1993-11-16 US claimed