Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.81 |
| ▸ | CASP6 | P55212 | 2/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 2/20 | 0.81 |
| ▸ | TDP2 | O95551 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | RAD52 | P43351 | 1/20 | 0.81 |
| ▸ | DRD2 | P14416 | 5/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.78 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.78 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | APAF1 | O14727 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 1/20 | 0.78 |
| ▸ | CASP7 | P55210 | 1/20 | 0.78 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.78 |
| ▸ | BCHE | P06276 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dicentrine SCHEMBL679684 | 0.90 | KDM4E (1.00) | POLBCASP6KMT2AKDM4ELMNA | |
| Dicentrine SCHEMBL28850766 | 0.90 | KDM4E (1.00) | POLBCASP6KMT2AKDM4ELMNA | |
| Dicentrine SCHEMBL6369440 | 0.90 | KDM4E (1.00) | POLBCASP6KMT2AKDM4ELMNA | |
| Dicentrine SCHEMBL30475130 | 0.90 | KDM4E (1.00) | POLBCASP6KMT2AKDM4ELMNA | |
| Roemerine SCHEMBL17906539 | 0.88 | DRD2 (1.00) | POLBCASP6KMT2AKDM4ELMNA | |
| Roemerine SCHEMBL673805 | 0.88 | DRD2 (1.00) | POLBCASP6KMT2AKDM4ELMNA | |
| Roemerine SCHEMBL678048 | 0.88 | DRD2 (1.00) | POLBCASP6KMT2AKDM4ELMNA | |
| Roemerine SCHEMBL30047807 | 0.88 | DRD2 (1.00) | POLBCASP6KMT2AKDM4ELMNA | |
| Roemerine SCHEMBL30047645 | 0.88 | DRD2 (1.00) | POLBCASP6KMT2AKDM4ELMNA | |
| SCHEMBL11249155 | 0.87 | DRD2 (0.74) | POLBCASP6KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118703454-A | Cytochrome P450 enzyme from stephania tetrandra and application thereof in biosynthesis of aporphine alkaloid compound | 中国中医科学院中药研究所 | 2024-09-27 | — | — | CN | disclosed |
| CN-118547022-A | Preparation method of aporphine alkaloid compound and related catalytic enzyme and application thereof | 中国中医科学院中药研究所 | 2024-08-27 | — | — | CN | disclosed |