Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.84 |
| ▸ | LMNA | P02545 | 4/20 | 0.84 |
| ▸ | MAPT | P10636 | 4/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.84 |
| ▸ | POLB | P06746 | 2/20 | 0.84 |
| ▸ | TDP2 | O95551 | 1/20 | 0.84 |
| ▸ | RAD52 | P43351 | 1/20 | 0.84 |
| ▸ | CASP6 | P55212 | 1/20 | 0.84 |
| ▸ | APP | P05067 | 1/20 | 0.72 |
| ▸ | BCHE | P06276 | 2/20 | 0.70 |
| ▸ | ACHE | P22303 | 2/20 | 0.70 |
| ▸ | DRD2 | P14416 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | HPGD | P15428 | 5/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.69 |
| ▸ | DRD1 | P21728 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cassythicine SCHEMBL30883018 | 1.00 | KDM4E (0.84) | KDM4ELMNAMAPTKMT2APOLB | |
| Dicentrine SCHEMBL6369440 | 0.92 | KDM4E (1.00) | KDM4ELMNAMAPTKMT2APOLB | |
| Dicentrine SCHEMBL31237335 | 0.92 | KDM4E (1.00) | KDM4ELMNAMAPTKMT2APOLB | |
| Dicentrine SCHEMBL31237199 | 0.92 | KDM4E (1.00) | KDM4ELMNAMAPTKMT2APOLB | |
| Dicentrine SCHEMBL30475130 | 0.92 | KDM4E (1.00) | KDM4ELMNAMAPTKMT2APOLB | |
| Dicentrine SCHEMBL679684 | 0.92 | KDM4E (1.00) | KDM4ELMNAMAPTKMT2APOLB | |
| Dicentrine SCHEMBL28850766 | 0.92 | KDM4E (1.00) | KDM4ELMNAMAPTKMT2APOLB | |
| Neolitsine SCHEMBL31029789 | 0.86 | POLB (0.81) | KDM4ELMNAMAPTKMT2APOLB | |
| SCHEMBL5659112 | 0.83 | DRD1 (0.79) | KDM4ELMNAMAPTKMT2APOLB | |
| SCHEMBL14367903 | 0.83 | DRD1 (0.79) | KDM4ELMNAMAPTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118703454-A | Cytochrome P450 enzyme from stephania tetrandra and application thereof in biosynthesis of aporphine alkaloid compound | 中国中医科学院中药研究所 | 2024-09-27 | — | — | CN | disclosed |
| CN-118547022-A | Preparation method of aporphine alkaloid compound and related catalytic enzyme and application thereof | 中国中医科学院中药研究所 | 2024-08-27 | — | — | CN | disclosed |