Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15084352 | 0.79 | FAAH (0.49) | FAAHDRD4HTR1AHTR7PDE2A | |
| SCHEMBL17289123 | 0.79 | FAAH (0.65) | FAAHDRD4HTR1AHTR7MCHR1 | |
| SCHEMBL1331198 | 0.79 | FAAH (0.65) | FAAHDRD4HTR1AHTR7MCHR1 | |
| SCHEMBL6584608 | 0.74 | FAAH (0.60) | FAAHDRD4HTR1AHTR7PDE2A | |
| SCHEMBL6793565 | 0.74 | KMT2A (0.55) | FAAHDRD4CYP2D6MCHR1OPRM1 | |
| SCHEMBL14197738 | 0.74 | DRD4 (0.51) | FAAHDRD4HTR1AHTR7PDE2A | |
| SCHEMBL28824423 | 0.73 | FAAH (0.56) | FAAHDRD4HTR1AHTR7PDE2A | |
| Hydrochloric Acid SCHEMBL4221712 | 0.72 | DRD4 (0.50) | FAAHDRD4HTR1AHTR7PDE2A | |
| SCHEMBL6797082 | 0.72 | DPP4 (0.54) | FAAH | |
| SCHEMBL1331766 | 0.72 | HRH3 (0.63) | FAAHDRD4HTR1AHTR7CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |