SCHEMBL6797915

SCHEMBL6797915

COc1cc(CCNC(=O)/C(=C/OC(F)F)c2ccc3ccccc3c2)ccc1O

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NOX4 Q9NPH5 1/20 0.46
MAPT P10636 3/20 0.46
RXFP1 Q9HBX9 1/20 0.46
APP P05067 1/20 0.45
TYR P14679 1/20 0.44
ACHE P22303 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
ALDH1A1 P00352 3/20 0.43
XDH P47989 1/20 0.43
MTNR1A P48039 1/20 0.43
MTNR1B P49286 1/20 0.43
KMT2A Q03164 1/20 0.42
HPGD P15428 1/20 0.42
PKM P14618 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6797921 1.00 NOX4 (0.46) NOX4MAPTRXFP1APPTYR
SCHEMBL6800751 0.93 MAPT (0.54) MAPTRXFP1ALDH1A1KMT2AHPGD
SCHEMBL6800756 0.93 MAPT (0.54) MAPTRXFP1ALDH1A1KMT2AHPGD
SCHEMBL6801820 0.91 NOX4 (0.51) NOX4MAPTTYRACHEALDH1A1
SCHEMBL6801821 0.91 NOX4 (0.51) NOX4MAPTTYRACHEALDH1A1
SCHEMBL6807705 0.90 MAPT (0.48) NOX4MAPTTYRACHEHDAC1
SCHEMBL6807707 0.90 MAPT (0.48) NOX4MAPTTYRACHEHDAC1
SCHEMBL6797880 0.88 ALDH1A1 (0.52) NOX4MAPTTYRACHEHDAC1
SCHEMBL6803649 0.88 NOX4 (0.48) NOX4TYRACHEHDAC1HDAC6
SCHEMBL6802209 0.88 NOX4 (0.48) NOX4MAPTTYRACHEHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6762321-B2 SUCH AS N-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-3-DIFLUOROMETHOXY-2-(4 -METHYLPHENYL)ACRYLAMIDE; FUNGICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-07-13 US disclosed
US-20030195354-A1 Amide compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-10-16 US disclosed
EP-1295868-A1 AMIDE COMPOUNDS AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-03-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030195354-A1 Amide compounds and use thereof CBR1, CBR3, NAT1 NOX4 331/4885MAPT 3676/4885RXFP1 681/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.