Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602658 | 0.87 | HPGD (0.42) | TP53MDM2ALDH1A1L3MBTL1LMNA | |
| SCHEMBL6804874 | 0.87 | L3MBTL1 (0.40) | TP53MDM2ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL6601551 | 0.83 | LTA4H (0.45) | TP53ALDH1A1SMN1; SMN2PPARGPPARA | |
| SCHEMBL6805998 | 0.83 | HPGD (0.41) | TP53MDM2ALDH1A1L3MBTL1LMNA | |
| SCHEMBL6604189 | 0.81 | MAPT (0.43) | ALDH1A1L3MBTL1MEN1LMNAKMT2A | |
| SCHEMBL6602333 | 0.81 | HPGD (0.38) | TP53MDM2L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL6604163 | 0.80 | S1PR4 (0.40) | TP53MDM2ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL6618274 | 0.80 | HTR1B (0.42) | TP53MDM2ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL6605678 | 0.80 | KMT2A (0.40) | TP53MDM2ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL6805954 | 0.80 | MRGPRX4 (0.38) | L3MBTL1MAPTPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | MKI67, CDK4, FLT4 | TP53 35/4885MDM2 1509/4885ALDH1A1 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.