Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.56 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.48 |
| ▸ | SCN4A | P35499 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.48 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680642 | 0.88 | SCN9A (0.50) | SCN9ASCN5APTPN1 | |
| SCHEMBL680374 | 0.88 | SCN9A (0.49) | SCN9ASCN5ASCN1ABCL2L1MCL1 | |
| SCHEMBL678866 | 0.87 | SCN9A (0.53) | SCN9ASCN5AABCB11CYP2C9SCN1A | |
| SCHEMBL680159 | 0.86 | CXCL8 (0.59) | SCN9ASCN5ASCN3ABCL2L1MCL1 | |
| SCHEMBL680346 | 0.86 | SCN9A (0.57) | SCN9ASCN5ASCN1ABCL2L1MCL1 | |
| SCHEMBL703171 | 0.84 | BCL2L1 (0.59) | SCN9ASCN5ASCN1ASCN3ABCL2L1 | |
| SCHEMBL16319538 | 0.84 | SLC6A4 (0.50) | SCN9ASCN5ABCL2L1MCL1CXCL8 | |
| SCHEMBL680206 | 0.82 | SOS1 (0.50) | SCN9ASCN3ABCL2L1MCL1SMN1; SMN2 | |
| SCHEMBL681087 | 0.82 | SCN9A (0.54) | SCN9ASCN5ASCN3ABCL2L1MCL1 | |
| SCHEMBL679760 | 0.81 | BCL2L1 (0.49) | SCN9ASCN5ASCN1ASCN3ABCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | SCN9A 13/4885SCN5A 5/4885ABCB11 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.