Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10044907 | 0.81 | RAB9A (0.43) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL12344428 | 0.80 | ALDH1A1 (0.46) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL8221474 | 0.80 | NPC1 (0.46) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL769313 | 0.80 | NPC1 (0.54) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL14682173 | 0.80 | ALDH1A1 (0.46) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL11540789 | 0.80 | ALDH1A1 (0.46) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL11540786 | 0.80 | ALDH1A1 (0.46) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL20205919 | 0.76 | MAPT (0.46) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL8027812 | 0.76 | KDM4E (0.43) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL3716710 | 0.75 | GSK3B (0.48) | MAPTRAB9ANPC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750243-B1 | COMPETITIVE INHIBITORS OF TRYPSIN-LIKE SERINE PROTEASES, ESPECIALLY THROMBIN; chemical synthesis; anticoagulants; treatment of thrombosis | AstraZeneća AB (SE) | 2004-06-15 | — | — | US | claimed |