Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 8/20 | 0.46 |
| ▸ | PDE1A | P54750 | 6/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.46 |
| ▸ | PDE2A | O00408 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15943410 | 0.93 | PDE1B (0.47) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL680017 | 0.88 | PDE1B (0.41) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL678876 | 0.85 | PDE1A (0.48) | PDE1BPDE1APDE1CPDE2ALMNA | |
| SCHEMBL679944 | 0.83 | PDE1B (0.47) | PDE1BPDE1APDE1CPDE2ALMNA | |
| SCHEMBL676398 | 0.81 | PTGS2 (0.46) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL3083046 | 0.76 | PDE1B (0.53) | PDE1BPDE1APDE1CPDE2AMEN1 | |
| SCHEMBL680616 | 0.76 | PDE1B (0.44) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL194205 | 0.76 | PDE1B (0.69) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL680003 | 0.75 | USP1 (0.48) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL680240 | 0.74 | PDE1B (0.44) | PDE1BPDE1APDE1CPDE2APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9487527-B2 | Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives useful as inhibitors of phosphodiesterase I | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-11-08 | — | — | US | disclosed |
| US-20150119370-A1 | Organic Compounds | LI PENG (US) | 2015-04-30 | — | — | US | disclosed |
| US-8859564-B2 | Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives useful as inhibitors of phosphodiesterase 1 | INTRA-CELLULAR THERAPIES, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20110281832-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281832-A1 | ORGANIC COMPOUNDS | CYP2C9, CYP2C19, CYP3A4 | PDE1B 4855/4885PDE1A 4874/4885PDE1C 4854/4885 |
| US-20150119370-A1 | Organic Compounds | CYP2C19, CYP2C9, CYP3A43 | PDE1B 4882/4885PDE1A 4885/4885PDE1C 4884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.