Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.68 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.68 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.68 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.53 |
| ▸ | RARB | P10826 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | RARA | P10276 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6799056 | 1.00 | S1PR1 (0.68) | S1PR1S1PR2S1PR3S1PR4ALDH1A1 | |
| SCHEMBL6803400 | 0.94 | S1PR2 (0.59) | S1PR1S1PR2S1PR3S1PR4ALDH1A1 | |
| SCHEMBL6807963 | 0.86 | S1PR2 (0.54) | S1PR1S1PR2S1PR3S1PR4ALDH1A1 | |
| SCHEMBL6801564 | 0.86 | S1PR2 (0.54) | S1PR1S1PR2S1PR3S1PR4ALDH1A1 | |
| SCHEMBL6228688 | 0.84 | S1PR2 (0.50) | S1PR1S1PR2S1PR3S1PR4ALDH1A1 | |
| SCHEMBL14195647 | 0.81 | S1PR1 (1.00) | S1PR1S1PR2S1PR3S1PR4ALDH1A1 | |
| SCHEMBL14195619 | 0.81 | S1PR1 (1.00) | S1PR1S1PR2S1PR3S1PR4ALDH1A1 | |
| SCHEMBL14195648 | 0.81 | S1PR1 (1.00) | S1PR1S1PR2S1PR3S1PR4ALDH1A1 | |
| SCHEMBL11837356 | 0.81 | ALDH1A1 (0.63) | S1PR1S1PR2S1PR3S1PR4ALDH1A1 | |
| SCHEMBL20854085 | 0.80 | ALDH1A1 (0.70) | S1PR1S1PR2S1PR3ALDH1A1RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063959-A1 | Esters and amides as PLA2 inhibitors | FUKAMI NAOKI (JP) | 2004-04-01 | — | — | US | disclosed |
| US-20020169326-A1 | Esters and amides as PLA2 inhibitors | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 2002-11-14 | — | — | US | disclosed |
| EP-0854863-B1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-10-30 | — | — | EP | disclosed |
| US-20020019416-A1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-14 | — | — | US | disclosed |
| EP-0854863-A1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |
| WO-1997003951-A1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063959-A1 | Esters and amides as PLA2 inhibitors | PLA2G4A, PLA2G2D, PLA2G4B | S1PR1 355/4885S1PR2 282/4885S1PR3 320/4885 |
| US-20020019416-A1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | PLA2G4A, PLA2G4B, PLA2G1B | S1PR1 252/4885S1PR2 240/4885S1PR3 251/4885 |
| US-20020169326-A1 | Esters and amides as PLA2 inhibitors | PLA2G4A, PLA2G2D, PLA2G4B | S1PR1 307/4885S1PR2 227/4885S1PR3 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.