SCHEMBL6800702

SCHEMBL6800702

Nc1nc(CCOc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)cs1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.47
TP53 P04637 4/20 0.47
LMNA P02545 2/20 0.47
PTGS1 P23219 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.44
SMO Q99835 1/20 0.44
OPRL1 P41146 1/20 0.43
MAPT P10636 1/20 0.43
MTTP P55157 6/20 0.42
APOB P04114 5/20 0.42
HTT P42858 1/20 0.42
POLB P06746 1/20 0.41
GAA P10253 1/20 0.41
TRPV1 Q8NER1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6788456 0.91 OPRL1 (0.48) RAB9ATP53LMNAPTGS1SMN1; SMN2
SCHEMBL6799168 0.90 TP53 (0.49) RAB9ATP53LMNASMN1; SMN2SMO
SCHEMBL6488310 0.88 SMN1; SMN2 (0.51) RAB9ATP53LMNASMN1; SMN2OPRL1
SCHEMBL6498339 0.88 SMN1; SMN2 (0.51) RAB9ATP53LMNASMN1; SMN2OPRL1
SCHEMBL6800205 0.88 TP53 (0.47) TP53LMNASMN1; SMN2SMOMAPT
SCHEMBL6794628 0.88 PTGS1 (0.48) TP53LMNAPTGS1SMN1; SMN2SMO
SCHEMBL6792997 0.88 TP53 (0.49) TP53LMNAPTGS1SMN1; SMN2SMO
SCHEMBL6795238 0.86 SMO (0.47) PTGS1SMN1; SMN2SMOOPRL1MTTP
SCHEMBL6795668 0.85 TP53 (0.54) TP53LMNAPTGS1SMN1; SMN2MAPT
Hydrochloric Acid SCHEMBL6801596 0.85 SMO (0.47) PTGS1SMN1; SMN2SMOOPRL1MTTP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US claimed
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors APOB, APOL1, SCARB1 RAB9A 3707/4885TP53 4865/4885LMNA 1239/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.