Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5881486 | 0.81 | GAA (0.66) | GAAALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL1928504 | 0.80 | GAA (0.67) | GAAALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL3499932 | 0.80 | GAA (0.71) | GAAALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL15012218 | 0.77 | LMNA (0.65) | GAAALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL17319189 | 0.77 | GAA (0.64) | GAAALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL14831873 | 0.76 | GAA (0.63) | GAAALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL16771569 | 0.76 | GAA (0.80) | GAAALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL20511052 | 0.76 | GAA (1.00) | GAAALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL6806069 | 0.75 | ADAM17 (0.39) | GAAALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL30636130 | 0.75 | GAA (0.78) | GAAALDH1A1LMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |