Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7059642 | 1.00 | CHRNB2 (0.57) | CHRNB2CHRNA7CHRNA4HPGDALDH1A1 | |
| SCHEMBL7059391 | 1.00 | CHRNB2 (0.57) | CHRNB2CHRNA7CHRNA4HPGDALDH1A1 | |
| SCHEMBL7062063 | 0.88 | CHRNB2 (0.48) | CHRNB2CHRNA7CHRNA4HPGDALDH1A1 | |
| SCHEMBL7063828 | 0.86 | CHRNA7 (0.45) | CHRNB2CHRNA7CHRNA4KMT2ANPC1 | |
| SCHEMBL7225655 | 0.86 | CHRNB2 (0.58) | CHRNB2CHRNA7CHRNA4HPGDALDH1A1 | |
| SCHEMBL7060781 | 0.85 | KMT2A (0.47) | CHRNB2CHRNA7CHRNA4HPGDALDH1A1 | |
| SCHEMBL7063255 | 0.84 | CHRNA7 (0.51) | CHRNB2CHRNA7CHRNA4HPGDALDH1A1 | |
| SCHEMBL7064073 | 0.82 | CHRNA7 (0.43) | CHRNB2CHRNA7CHRNA4NPC1RAB9A | |
| SCHEMBL6805064 | 0.82 | CHRNA7 (0.43) | CHRNB2CHRNA7CHRNA4NPC1RAB9A | |
| SCHEMBL6829677 | 0.82 | CHRNA7 (0.43) | CHRNB2CHRNA7CHRNA4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040157878-A1 | Compounds as radioligands for the diagnosis of disease | PHARMACIA & UPJOHN COMPANY | 2004-08-12 | — | — | US | claimed |
| US-20040157878-A1 | Compounds as radioligands for the diagnosis of disease | PHARMACIA & UPJOHN COMPANY | 2004-08-12 | — | — | US | disclosed |
| WO-2004052889-A1 | COMPOUNDS AS RADIOLIGANDS FOR THE DIAGNOSIS OF DISEASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157878-A1 | Compounds as radioligands for the diagnosis of disease | CHRNG, CHRNB1, CHRNE | CHRNB2 8/4885CHRNA7 14/4885CHRNA4 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.