Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.49 |
| ▸ | AKT2 | P31751 | 2/20 | 0.49 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.49 |
| ▸ | PDE2A | O00408 | 14/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680763 | 0.89 | AKT1 (0.51) | AKT1AKT2AKT3PDE2AEPHX2 | |
| SCHEMBL12188418 | 0.86 | AKT1 (0.53) | AKT1AKT2AKT3PDE2AEPHX2 | |
| SCHEMBL17803806 | 0.85 | LMNA (0.37) | AKT1AKT2AKT3 | |
| SCHEMBL680165 | 0.84 | AKT1 (0.36) | AKT1AKT2AKT3 | |
| SCHEMBL680195 | 0.84 | AKT1 (0.36) | AKT1AKT2AKT3EPHX2 | |
| SCHEMBL2738647 | 0.84 | AKT1 (0.51) | AKT1AKT2AKT3PDE2ACYP11B1 | |
| SCHEMBL681171 | 0.84 | EPHX2 (0.46) | PDE2AEPHX2 | |
| SCHEMBL681580 | 0.82 | ADRB2 (0.39) | AKT1PDE2A | |
| SCHEMBL681257 | 0.82 | TEAD1 (0.42) | AKT1AKT2AKT3EPHX2 | |
| SCHEMBL17803807 | 0.82 | HTR2A (0.40) | AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |