Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CBLB | Q13191 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087243 | 0.93 | ALDH1A1 (0.37) | ALDH1A1KDM4ETDP1MAPK14NAMPT | |
| SCHEMBL14725070 | 0.93 | ALDH1A1 (0.37) | ALDH1A1KDM4ETDP1MAPK14NAMPT | |
| SCHEMBL6087240 | 0.93 | ALDH1A1 (0.37) | ALDH1A1KDM4ETDP1MAPK14NAMPT | |
| SCHEMBL6087346 | 0.85 | MAPK14 (0.47) | MAPK14TSHR | |
| SCHEMBL6087855 | 0.83 | MAPK14 (0.40) | ALDH1A1KDM4EMAPK14NAMPTTP53 | |
| SCHEMBL6087853 | 0.83 | MAPK14 (0.40) | ALDH1A1KDM4EMAPK14NAMPTTP53 | |
| SCHEMBL14715793 | 0.83 | MAPK14 (0.40) | ALDH1A1KDM4EMAPK14NAMPTTP53 | |
| SCHEMBL6087089 | 0.83 | PDGFRB (0.40) | MAPK14NAMPTTP53ALOX15TOP1 | |
| SCHEMBL6087093 | 0.83 | PDGFRB (0.40) | MAPK14NAMPTTP53ALOX15TOP1 | |
| SCHEMBL6089198 | 0.81 | MAOA (0.44) | MAOATOP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040019098-A1 | (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors | ALLERGAN, INC. | 2004-01-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019098-A1 | (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors | CDK2, ERBB2, MAP3K3 | ALDH1A1 1606/4885KDM4E 1176/4885TDP1 1824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.