SCHEMBL6801546

SCHEMBL6801546

COc1ccc(C(=COC(F)F)C(=O)NCCc2ccc(OC)c(OC)c2)cc1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.58
MEN1 O00255 3/20 0.57
KMT2A Q03164 3/20 0.57
ALDH1A1 P00352 9/20 0.54
HPGD P15428 1/20 0.54
OPRM1 P35372 1/20 0.53
OPRD1 P41143 1/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
POLB P06746 1/20 0.53
GAA P10253 2/20 0.52
NPC1 O15118 1/20 0.51
LMNA P02545 1/20 0.51
HTT P42858 1/20 0.51
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6801543 1.00 MAPT (0.58) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL6807707 0.92 MAPT (0.48) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL6807705 0.92 MAPT (0.48) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL6796855 0.92 ALDH1A1 (0.62) MAPTKMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL6796850 0.92 ALDH1A1 (0.62) MAPTKMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL6802677 0.91 GAA (0.64) MAPTALDH1A1HPGDSMN1; SMN2GAA
SCHEMBL6801944 0.91 ALDH1A1 (0.58) MAPTALDH1A1HPGDSMN1; SMN2POLB
SCHEMBL6801943 0.91 ALDH1A1 (0.58) MAPTALDH1A1HPGDSMN1; SMN2POLB
SCHEMBL6802680 0.91 GAA (0.64) MAPTALDH1A1HPGDSMN1; SMN2GAA
SCHEMBL6799222 0.90 MAPT (0.48) MAPTMEN1KMT2AALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6762321-B2 SUCH AS N-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-3-DIFLUOROMETHOXY-2-(4 -METHYLPHENYL)ACRYLAMIDE; FUNGICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-07-13 US disclosed
US-20030195354-A1 Amide compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-10-16 US disclosed
EP-1295868-A1 AMIDE COMPOUNDS AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-03-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030195354-A1 Amide compounds and use thereof CBR1, CBR3, NAT1 MAPT 3676/4885MEN1 2217/4885KMT2A 1480/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.