Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | USP8 | P40818 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6800940 | 0.85 | GAK (0.54) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2656285 | 0.82 | GABRA1 (0.58) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL6799283 | 0.79 | NT5E (0.47) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL6804444 | 0.78 | FGFR1 (0.55) | GAKMEN1HPGDKMT2A | |
| SCHEMBL13202017 | 0.78 | KMT2A (0.52) | GAKMEN1PI4KAPI4K2BPI4K2A | |
| SCHEMBL6799091 | 0.78 | IDO1 (0.46) | CYP11B1CYP11B2MEN1CYP3A4CYP2A6 | |
| SCHEMBL13045092 | 0.76 | FGFR1 (0.57) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL6801219 | 0.75 | FGFR1 (0.57) | GAKPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL2647270 | 0.73 | GABRA1 (0.51) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2646283 | 0.72 | GABRA1 (0.58) | GABRG2GABRB3GABRA3GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723735-B1 | TREATMENT OR PREVENTION OF ANXIETY | MERCK SHARP & DOHME LTD. | 2004-04-20 | — | — | US | disclosed |
| EP-1214319-B1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-11-26 | — | — | EP | disclosed |
| EP-1214319-A1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | Merck Sharp & Dohme Limited (GB) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018000-A1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-03-15 | — | — | WO | disclosed |