Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.55 |
| ▸ | NT5E | P21589 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13202017 | 0.83 | KMT2A (0.52) | FGFR1RPS6KA3HPGDMEN1KMT2A | |
| SCHEMBL6801219 | 0.81 | FGFR1 (0.57) | FGFR1HPGDGAK | |
| SCHEMBL22699767 | 0.80 | FGFR1 (0.62) | FGFR1NT5EESR1ESR2RPS6KA3 | |
| SCHEMBL6801677 | 0.78 | GABRG2 (0.45) | HPGDMEN1KMT2AGAK | |
| SCHEMBL6799091 | 0.78 | IDO1 (0.46) | HPGDMEN1KMT2ASRC | |
| SCHEMBL6804619 | 0.76 | NT5E (0.69) | FGFR1NT5EESR1ESR2RPS6KA3 | |
| SCHEMBL29623847 | 0.75 | FGFR1 (0.43) | FGFR1HPGDKMT2AGAK | |
| SCHEMBL19350803 | 0.75 | FGFR1 (0.43) | FGFR1HPGDKMT2AGAK | |
| SCHEMBL6802476 | 0.74 | HPGD (0.44) | HPGDMEN1KMT2A | |
| SCHEMBL2409565 | 0.73 | NT5E (0.60) | FGFR1NT5EESR1ESR2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723735-B1 | TREATMENT OR PREVENTION OF ANXIETY | MERCK SHARP & DOHME LTD. | 2004-04-20 | — | — | US | disclosed |
| EP-1214319-B1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-11-26 | — | — | EP | disclosed |