Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11400226 | 0.79 | ALDH1A1 (0.67) | POLBPKMALDH1A1MAPTNPC1 | |
| SCHEMBL315313 | 0.78 | POLB (1.00) | POLBTSHRAPEX1ALDH1A1MAPT | |
| SCHEMBL14350433 | 0.76 | ALDH1A1 (0.46) | POLBTSHRAPEX1PKMALDH1A1 | |
| SCHEMBL20202250 | 0.74 | POLB (0.76) | POLBTSHRAPEX1PKMALDH1A1 | |
| SCHEMBL400161 | 0.72 | POLB (0.70) | POLBALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL11887838 | 0.72 | POLB (0.68) | POLBTSHRAPEX1ALDH1A1MAPT | |
| Piperazine SCHEMBL11396939 | 0.71 | ALDH1A1 (0.58) | POLBPKMALDH1A1MAPTNPC1 | |
| SCHEMBL19717836 | 0.71 | POLB (0.68) | POLBTSHRAPEX1PKMALDH1A1 | |
| Bromide SCHEMBL27289520 | 0.71 | POLB (0.68) | POLBALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL16520814 | 0.71 | POLB (0.67) | POLBTSHRAPEX1PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828427-B1 | Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |
| US-6750344-B1 | MONOCYCLIC AMINE SCAFFOLD BEARING AT LEAST TWO SITES OF DIVERSITY, CYCLIZED TO FORM BICYCLIC AMINE SCAFFOLDS; 7-AMINO-PYRROLO(1,2-A)PYRAZIN-4-ONE COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-6316626-B1 | Amine compounds and combinatorial libraries comprising same | ISIS PHARMACEUTICALS, INC. | 2001-11-13 | — | — | US | disclosed |