Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | FABP7 | O15540 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796420 | 0.83 | FABP5 (0.37) | MDM4TP53FABP5OPRD1FABP7 | |
| SCHEMBL6798554 | 0.83 | FABP5 (0.37) | MDM4TP53FABP5OPRD1FABP7 | |
| SCHEMBL8729183 | 0.77 | LMNA (0.39) | MDM4TP53FABP5OPRD1FABP7 | |
| SCHEMBL8729229 | 0.77 | LMNA (0.39) | MDM4TP53FABP5OPRD1FABP7 | |
| SCHEMBL6853795 | 0.77 | LMNA (0.39) | MDM4TP53FABP5OPRD1FABP7 | |
| SCHEMBL6856330 | 0.73 | FABP5 (0.33) | MDM4TP53FABP5FABP7 | |
| SCHEMBL6855668 | 0.72 | FABP5 (0.37) | MDM4TP53FABP5OPRD1FABP7 | |
| SCHEMBL6858060 | 0.72 | FABP5 (0.37) | MDM4TP53FABP5OPRD1FABP7 | |
| SCHEMBL6858228 | 0.72 | FABP5 (0.37) | MDM4TP53FABP5FABP7 | |
| SCHEMBL8732800 | 0.72 | FABP5 (0.37) | MDM4TP53FABP5OPRD1FABP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750344-B1 | MONOCYCLIC AMINE SCAFFOLD BEARING AT LEAST TWO SITES OF DIVERSITY, CYCLIZED TO FORM BICYCLIC AMINE SCAFFOLDS; 7-AMINO-PYRROLO(1,2-A)PYRAZIN-4-ONE COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-6316626-B1 | Amine compounds and combinatorial libraries comprising same | ISIS PHARMACEUTICALS, INC. | 2001-11-13 | — | — | US | disclosed |
| WO-1999012034-A1 | AMINE COMPOUNDS AND COMBINATORIAL LIBRARIES COMPRISING SAME | ISIS PHARMACEUTICALS, INC. (US) | 1999-03-11 | — | — | WO | disclosed |