Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680237 | 0.88 | MEN1 (0.48) | MEN1MITFKMT2AOPRL1 | |
| SCHEMBL680871 | 0.88 | FPR2 (0.38) | MEN1MITFKMT2AFPR2KDM1A | |
| SCHEMBL681242 | 0.88 | AKT1 (0.37) | FPR2KDM1AMAOAMAOBHSD11B1 | |
| SCHEMBL14300654 | 0.85 | FPR2 (0.39) | MEN1MITFKMT2AFPR2KDM1A | |
| SCHEMBL2739168 | 0.83 | FPR2 (0.39) | KMT2AFPR2KDM1AMAOAMAOB | |
| SCHEMBL680798 | 0.78 | FPR2 (0.39) | FPR2KDM1AMAOAMAOBPOLB | |
| SCHEMBL17803811 | 0.77 | TSHR (0.38) | HSD11B1POLB | |
| SCHEMBL679786 | 0.76 | MEN1 (0.48) | MEN1MITFKMT2APOLBOPRL1 | |
| SCHEMBL681300 | 0.76 | AKT3 (0.47) | MEN1MITFKMT2AHSD11B1OPRL1 | |
| SCHEMBL681244 | 0.76 | MEN1 (0.50) | MEN1MITFKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |