Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679804 | 0.88 | AVPR1A (0.41) | LMNAAVPR1A | |
| SCHEMBL680881 | 0.87 | AVPR1A (0.41) | POLBLMNAAVPR1AALDH1A1L3MBTL1 | |
| SCHEMBL20278026 | 0.86 | AVPR1A (0.42) | POLBSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL680886 | 0.85 | CYP2C9 (0.44) | RAB9AAVPR1AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL681663 | 0.80 | BCHE (0.50) | POLBEPHX1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL680890 | 0.79 | ACACB (0.44) | POLBSMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL20892764 | 0.79 | ACACB (0.44) | POLBSMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL681500 | 0.77 | SLC6A2 (0.46) | POLBSMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL683680 | 0.75 | LMNA (0.42) | POLBLMNAAVPR1A | |
| SCHEMBL12537186 | 0.75 | ACACB (0.57) | GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |