Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | MC5R | P33032 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | MC1R | Q01726 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681504 | 0.88 | GPR142 (0.42) | BCHEALDH1A1KDM1AMAOAMAOB | |
| SCHEMBL680254 | 0.80 | POLB (0.51) | SMN1; SMN2NPC1RAB9APOLBALDH1A1 | |
| SCHEMBL681837 | 0.79 | ACACB (0.42) | POLBALDH1A1KMT2A | |
| SCHEMBL681327 | 0.79 | GAA (0.51) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL681060 | 0.78 | HTRA1 (0.46) | SMN1; SMN2POLBKMT2A | |
| SCHEMBL12188589 | 0.76 | GPR142 (0.43) | BCHEKDM1AMAOAMAOBAVPR1A | |
| SCHEMBL681505 | 0.76 | CNR2 (0.40) | SMN1; SMN2MEN1KMT2AAVPR1AMC4R | |
| SCHEMBL680890 | 0.75 | ACACB (0.44) | SMN1; SMN2RAB9APOLBALDH1A1MEN1 | |
| SCHEMBL20892764 | 0.75 | ACACB (0.44) | SMN1; SMN2RAB9APOLBALDH1A1MEN1 | |
| SCHEMBL680880 | 0.74 | GAA (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |