Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141345 | 1.00 | TAS2R14 (0.49) | TAS2R14CFTRAKR1B1AKR1C4AKR1C3 | |
| SCHEMBL6808607 | 0.88 | CCR1 (0.43) | TAS2R14CFTRAKR1B1AKR1C4AKR1C3 | |
| SCHEMBL6141291 | 0.86 | GAA (0.48) | TAS2R14CFTRAKR1B1AKR1C4AKR1C3 | |
| SCHEMBL6141255 | 0.85 | TAS2R14 (0.61) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL6140912 | 0.84 | TAS2R14 (0.60) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL6141240 | 0.84 | TAS2R14 (0.60) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL6141367 | 0.83 | TAS2R14 (0.46) | TAS2R14CFTRAKR1B1AKR1C4AKR1C3 | |
| SCHEMBL6141355 | 0.82 | TAS2R14 (0.54) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL6141233 | 0.81 | TAS2R14 (0.49) | TAS2R14CFTRAKR1B1AKR1C4AKR1C3 | |
| SCHEMBL6141349 | 0.80 | TAS2R14 (0.55) | TAS2R14CFTRAKR1B1AKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | POLRMT, POLR1E, CTDSP1 | TAS2R14 4336/4885CFTR 474/4885AKR1B1 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.