Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3557231 | 1.00 | SIGMAR1 (0.49) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL12916351 | 0.84 | PIM1 (0.39) | SIGMAR1HTR2AHTR2CHTR2BPIM1 | |
| SCHEMBL22542012 | 0.84 | PIM1 (0.39) | SIGMAR1HTR2AHTR2CHTR2BPIM1 | |
| SCHEMBL13808671 | 0.84 | PIM1 (0.39) | SIGMAR1HTR2AHTR2CHTR2BPIM1 | |
| SCHEMBL24028089 | 0.82 | PIM1 (0.38) | SIGMAR1HTR2AHTR2CHTR2BPIM1 | |
| SCHEMBL16853407 | 0.82 | HDAC1 (0.39) | SIGMAR1HTR2AHTR2CHTR2BPIM1 | |
| SCHEMBL11019668 | 0.82 | PIM1 (0.38) | SIGMAR1HTR2AHTR2CHTR2BPIM1 | |
| SCHEMBL4935360 | 0.82 | PIM1 (0.44) | SIGMAR1HTR2AHTR2CHTR2BPIM1 | |
| SCHEMBL4939560 | 0.82 | PIM1 (0.38) | SIGMAR1HTR2AHTR2CHTR2BPIM1 | |
| SCHEMBL4935362 | 0.82 | PIM1 (0.44) | SIGMAR1HTR2AHTR2CHTR2BPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828427-B1 | Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |
| US-6750344-B1 | MONOCYCLIC AMINE SCAFFOLD BEARING AT LEAST TWO SITES OF DIVERSITY, CYCLIZED TO FORM BICYCLIC AMINE SCAFFOLDS; 7-AMINO-PYRROLO(1,2-A)PYRAZIN-4-ONE COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-6316626-B1 | Amine compounds and combinatorial libraries comprising same | ISIS PHARMACEUTICALS, INC. | 2001-11-13 | — | — | US | disclosed |