Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5485928 | 0.80 | CCR4 (0.38) | HRH4HRH3KCNH2ENPP1KDM4E | |
| SCHEMBL5485932 | 0.80 | CCR4 (0.38) | HRH4HRH3KCNH2ENPP1KDM4E | |
| SCHEMBL5485648 | 0.78 | HRH4 (0.42) | HRH4HRH3KCNH2ENPP1PDE10A | |
| SCHEMBL5484986 | 0.78 | ENPP1 (0.44) | HRH4HRH3KCNH2ENPP1PDE10A | |
| SCHEMBL5485646 | 0.78 | HRH4 (0.42) | HRH4HRH3KCNH2ENPP1PDE10A | |
| SCHEMBL5484991 | 0.78 | ENPP1 (0.44) | HRH4HRH3KCNH2ENPP1PDE10A | |
| Hydrochloric Acid SCHEMBL5485950 | 0.77 | HRH4 (0.41) | HRH4HRH3KCNH2ENPP1PDE10A | |
| Hydrochloric Acid SCHEMBL5485955 | 0.77 | HRH4 (0.41) | HRH4HRH3KCNH2ENPP1PDE10A | |
| SCHEMBL5486348 | 0.72 | ENPP1 (0.43) | ENPP1PDE10ACYP3A4NPY5R | |
| SCHEMBL5486343 | 0.72 | ENPP1 (0.43) | ENPP1PDE10ACYP3A4NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040029901-A1 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029901-A1 | Quinazoline derivatives | GPR119, NQO2, CYP7A1 | HRH4 529/4885HRH3 1196/4885KCNH2 2426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.