Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 13/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057901 | 1.00 | CHRNA7 (0.65) | CHRNA7CHRNB2CHRNA4HDAC3HDAC4 | |
| SCHEMBL7115498 | 0.86 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4HDAC3HDAC4 | |
| SCHEMBL7129015 | 0.85 | CHRNA7 (0.51) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7057906 | 0.85 | CHRNA7 (0.49) | CHRNA7CHRNB2CHRNA4KDM4ENPC1 | |
| SCHEMBL7064066 | 0.84 | CHRNA7 (0.61) | CHRNA7CHRNB2CHRNA4HDAC1KDM4E | |
| SCHEMBL7219699 | 0.84 | CHRNA7 (0.48) | CHRNA7CHRNB2CHRNA4KDM4ENPC1 | |
| SCHEMBL7059646 | 0.84 | CHRNA7 (0.50) | CHRNA7CHRNB2CHRNA4HDAC1HTR3E | |
| SCHEMBL7063779 | 0.83 | CHRNA7 (0.49) | CHRNA7CHRNB2CHRNA4HDAC1KDM4E | |
| SCHEMBL7220613 | 0.83 | CHRNA7 (0.54) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7061274 | 0.83 | CHRNA7 (0.54) | CHRNA7CHRNB2CHRNA4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040157878-A1 | Compounds as radioligands for the diagnosis of disease | PHARMACIA & UPJOHN COMPANY | 2004-08-12 | — | — | US | claimed |
| WO-2004052889-A1 | COMPOUNDS AS RADIOLIGANDS FOR THE DIAGNOSIS OF DISEASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-06-24 | — | — | WO | claimed |
| US-20040157878-A1 | Compounds as radioligands for the diagnosis of disease | PHARMACIA & UPJOHN COMPANY | 2004-08-12 | — | — | US | disclosed |
| WO-2004052889-A1 | COMPOUNDS AS RADIOLIGANDS FOR THE DIAGNOSIS OF DISEASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157878-A1 | Compounds as radioligands for the diagnosis of disease | CHRNG, CHRNB1, CHRNE | CHRNA7 14/4885CHRNB2 8/4885CHRNA4 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.