Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3962717 | 0.85 | SMN1; SMN2 (0.50) | ALDH1A1KDM4ERAB9ASMN1; SMN2HTT | |
| SCHEMBL3969728 | 0.84 | CYP1A2 (0.51) | ALDH1A1KDM4ERAB9ASMN1; SMN2HTT | |
| SCHEMBL3962723 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1KDM4ERAB9ASMN1; SMN2HTT | |
| SCHEMBL6805411 | 0.82 | CYP1A2 (0.49) | ALDH1A1KDM4ERAB9ASMN1; SMN2HTT | |
| SCHEMBL3970733 | 0.80 | SMN1; SMN2 (0.47) | ALDH1A1KDM4ERAB9ASMN1; SMN2HTT | |
| SCHEMBL3970739 | 0.80 | NCF1 (0.51) | ALDH1A1KDM4ERAB9ASMN1; SMN2HTT | |
| SCHEMBL3970289 | 0.78 | SMN1; SMN2 (0.47) | ALDH1A1KDM4ERAB9ASMN1; SMN2HTT | |
| SCHEMBL3970211 | 0.78 | ADAM17 (0.57) | — | |
| SCHEMBL6805409 | 0.72 | CYP1A2 (0.44) | ALDH1A1KDM4ERAB9ASMN1; SMN2HTT | |
| SCHEMBL3964963 | 0.72 | CYP1A2 (0.50) | ALDH1A1RAB9ASMN1; SMN2HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |