Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.37 |
| ▸ | MMP1 | P03956 | 8/20 | 0.37 |
| ▸ | MMP3 | P08254 | 5/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 3/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676288 | 0.99 | TUBB1 (0.51) | TUBB1ADAM17MMP1MMP3MMP2 | |
| SCHEMBL6670504 | 0.88 | TUBB1 (0.62) | TUBB1ADAM17MMP1MMP3MMP2 | |
| SCHEMBL14591310 | 0.87 | TUBB1 (0.63) | TUBB1ADAM17MMP1MMP3MMP2 | |
| SCHEMBL58360 | 0.87 | TUBB1 (0.63) | TUBB1ADAM17MMP1MMP3MMP2 | |
| Trifluoroacetic Acid SCHEMBL6805156 | 0.84 | TUBB1 (0.58) | TUBB1ADAM17MMP1MMP3MMP2 | |
| Trifluoroacetic Acid SCHEMBL6682843 | 0.83 | TUBB1 (0.59) | TUBB1ADAM17MMP1MMP3MMP2 | |
| SCHEMBL6805158 | 0.81 | TUBB1 (0.51) | TUBB1ADAM17MMP1MMP3MMP2 | |
| SCHEMBL58029 | 0.81 | TUBB1 (0.61) | TUBB1ADAM17MMP1MMP3MMP2 | |
| SCHEMBL13848318 | 0.81 | TUBB1 (0.61) | TUBB1ADAM17MMP1MMP3MMP2 | |
| SCHEMBL6671811 | 0.80 | TUBB1 (0.41) | TUBB1ADAM17MMP1MMP3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040121965-A1 | Method of treating resistant tumors | WYETH HOLDINGS CORPORATION (US) | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121965-A1 | Method of treating resistant tumors | SLC11A2, VHL, REN | TUBB1 199/4885ADAM17 1762/4885MMP1 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.