Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804602 | 0.84 | PIM1 (0.63) | PARP1AURKBPIM1PIM3CLK4 | |
| SCHEMBL6806425 | 0.82 | PARP1 (0.45) | PARP1AURKBPIM1PIM3CLK4 | |
| SCHEMBL6810605 | 0.79 | AURKB (0.44) | PARP1AURKBPIM1PIM3CLK4 | |
| SCHEMBL7140624 | 0.78 | PARP1 (0.48) | PARP1AURKBPIM1PIM3CLK4 | |
| SCHEMBL6810283 | 0.78 | PARP1 (0.42) | PARP1AURKBPIM1PIM3CLK4 | |
| SCHEMBL3575241 | 0.78 | MAP4K4 (0.72) | PARP1AURKBPIM1PIM3CLK4 | |
| SCHEMBL6803462 | 0.77 | AURKB (0.48) | PARP1AURKBPIM1PIM3CLK4 | |
| SCHEMBL3575819 | 0.77 | CHEK1 (0.65) | PARP1AURKBPIM1PIM3CLK4 | |
| SCHEMBL6806544 | 0.77 | PIM1 (0.46) | PARP1AURKBPIM1PIM3CLK4 | |
| SCHEMBL6806674 | 0.76 | PARP1 (0.39) | PARP1AURKBPIM1PIM3CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |