Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.50 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SCN2B | O60939 | 1/20 | 0.43 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679975 | 0.89 | SCN9A (0.56) | SCN9AIGFBP3SCN2BSCN1BSCN5A | |
| SCHEMBL679043 | 0.88 | SCN9A (0.51) | SCN9ASCN2BSCN1BSCN5A | |
| SCHEMBL21628451 | 0.87 | HDAC1 (0.56) | IGFBP3MMP13MAPTMAPK1KCNQ3 | |
| SCHEMBL679029 | 0.85 | SCN9A (0.56) | SCN9A | |
| SCHEMBL680642 | 0.85 | SCN9A (0.50) | SCN9AMMP13MAPTMAPK1SCN5A | |
| SCHEMBL1690181 | 0.84 | SCN9A (0.50) | SCN9ASCN5AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL16319310 | 0.84 | SCN9A (0.71) | SCN9AIGFBP3SCN5A | |
| SCHEMBL21656765 | 0.84 | MMP13 (0.65) | IGFBP3MMP13MAPTMAPK1KCNQ3 | |
| SCHEMBL680213 | 0.82 | SCN9A (0.54) | SCN9ASCN2BSCN1BSCN5APTPN1 | |
| SCHEMBL680082 | 0.82 | SCN9A (0.72) | SCN9ASCN2BSCN1BSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | SCN9A 13/4885IGFBP3 4773/4885MMP13 4543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.