Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | NMT1 | P30419 | 6/20 | 0.44 |
| ▸ | MAOB | P27338 | 6/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969638 | 0.84 | FFAR1 (0.52) | FFAR1NMT1MAOBMMP1ADAM17 | |
| SCHEMBL3969642 | 0.79 | ALDH1A1 (0.57) | FFAR1NMT1MMP1ADAM17MMP13 | |
| SCHEMBL14675544 | 0.79 | FFAR1 (0.60) | FFAR1FFAR4 | |
| Hydrochloric Acid SCHEMBL14675781 | 0.78 | FFAR1 (0.59) | FFAR1FFAR4 | |
| SCHEMBL3962715 | 0.77 | FFAR1 (0.51) | FFAR1NMT1MAOBMMP1ADAM17 | |
| SCHEMBL3962712 | 0.77 | FFAR1 (0.51) | FFAR1NMT1MAOBMMP1ADAM17 | |
| SCHEMBL14676869 | 0.76 | FFAR1 (0.57) | FFAR1MAOB | |
| SCHEMBL6800379 | 0.75 | ALDH1A1 (0.63) | MAOB | |
| SCHEMBL4053035 | 0.74 | FFAR1 (0.48) | FFAR1NMT1MAOBMMP1ADAM17 | |
| SCHEMBL6810574 | 0.73 | MMP13 (0.44) | FFAR1MAOBMMP1ADAM17MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |