Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805596 | 0.91 | PARP1 (0.57) | PARP1PLK4MAPK13DYRK3ROCK2 | |
| SCHEMBL6806553 | 0.90 | PARP1 (0.59) | PARP1LMNAMAPTTSHRMAPK1 | |
| SCHEMBL6805843 | 0.89 | PARP1 (0.56) | PARP1PLK4MAPK13DYRK3ROCK2 | |
| SCHEMBL6589391 | 0.78 | LMNA (0.46) | PARP1LMNAMAPTTSHRMAPK1 | |
| SCHEMBL29412077 | 0.75 | PARP1 (0.78) | PARP1PLK4MAPK13DYRK3ROCK2 | |
| SCHEMBL6806559 | 0.74 | SMN1; SMN2 (0.53) | PARP1LMNAMAPTTSHRMAPK1 | |
| SCHEMBL6806661 | 0.73 | PARP1 (0.56) | PARP1DHODH | |
| SCHEMBL2299805 | 0.69 | PARP1 (0.79) | PARP1PLK4MAPK13DYRK3ROCK2 | |
| SCHEMBL6807472 | 0.69 | PARP1 (0.56) | PARP1PLK4MAPK13DYRK3ROCK2 | |
| SCHEMBL6804341 | 0.69 | PARP1 (0.51) | PARP1PLK4MAPK13DYRK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |