Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 11/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806553 | 0.85 | PARP1 (0.59) | LMNAMAPTTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL6805066 | 0.78 | PARP1 (0.50) | LMNAMAPTTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL6805596 | 0.76 | PARP1 (0.57) | PARP1CHEK2 | |
| SCHEMBL7765824 | 0.76 | PARP1 (0.43) | PARP1CHEK2MGAMGAASI | |
| SCHEMBL6591702 | 0.75 | PARP1 (0.44) | LMNASMN1; SMN2PARP1CHEK2MGAM | |
| SCHEMBL6806559 | 0.74 | SMN1; SMN2 (0.53) | LMNAMAPTTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL6587289 | 0.73 | PARP1 (0.49) | PARP1CHEK2MGAMGAASI | |
| SCHEMBL6590978 | 0.72 | PARP1 (0.42) | PARP1MGAMGAASIMGAM2 | |
| SCHEMBL6591596 | 0.72 | PARP1 (0.48) | PARP1CHEK2MGAMGAASI | |
| SCHEMBL6805843 | 0.71 | PARP1 (0.56) | PARP1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |