Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.65 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.64 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585146 | 0.86 | PARP1 (0.47) | PARP1PLA2G2AALOX15PTGS2DHODH | |
| SCHEMBL6805081 | 0.84 | PARP1 (0.48) | PARP1PLA2G2AALOX15PTGS2 | |
| SCHEMBL6807494 | 0.84 | PARP1 (0.63) | PARP1PKN1PKN2CHEK2DHODH | |
| SCHEMBL6802028 | 0.83 | PARP1 (0.66) | PARP1PKN1PKN2CHEK2DHODH | |
| SCHEMBL6810193 | 0.80 | PARP1 (0.55) | PARP1PLA2G2AALOX15PTGS2PKN1 | |
| SCHEMBL4321727 | 0.79 | PARP1 (1.00) | PARP1PLA2G2AALOX15PTGS2PKN1 | |
| SCHEMBL7319077 | 0.79 | PARP1 (1.00) | PARP1PLA2G2AALOX15PTGS2PKN1 | |
| SCHEMBL3117270 | 0.76 | ATP4A (0.46) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL3633587 | 0.74 | NR4A2 (0.73) | — | |
| SCHEMBL14023455 | 0.73 | NOX1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |