Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805307 | 0.83 | PARP1 (0.65) | PARP1DHODH | |
| SCHEMBL6806933 | 0.80 | PARP1 (0.39) | PARP1DHODHBRD4NPC1RAB9A | |
| SCHEMBL3579908 | 0.80 | PARP1 (0.61) | PARP1GAADHODHNPC1RAB9A | |
| SCHEMBL6805469 | 0.76 | NPC1 (0.43) | PARP1MEN1KMT2ADHODHBRD4 | |
| SCHEMBL29696369 | 0.74 | NPC1 (0.53) | PARP1DHODHNPC1RAB9ACYP3A4 | |
| SCHEMBL6800084 | 0.73 | PARP1 (0.44) | PARP1MEN1KMT2ADHODHRAB9A | |
| SCHEMBL6805349 | 0.72 | PARP1 (0.42) | PARP1BRD4 | |
| SCHEMBL6805519 | 0.72 | ALDH1A1 (0.48) | PARP1DHODHNPC1RAB9A | |
| SCHEMBL6587155 | 0.72 | PARP1 (0.44) | PARP1DHODHPTGS1 | |
| SCHEMBL6804274 | 0.72 | PARP1 (0.69) | PARP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |