Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29441612 | 0.80 | ALDH1A1 (0.52) | ALDH1A1HSD17B10KDM4ECA1CA2 | |
| SCHEMBL11213802 | 0.80 | ALDH1A1 (0.52) | ALDH1A1HSD17B10KDM4ECA1CA2 | |
| SCHEMBL11012927 | 0.78 | ALDH1A1 (0.40) | ALDH1A1HSD17B10KDM4EPOLB | |
| SCHEMBL2631833 | 0.77 | ALDH1A1 (0.48) | ALDH1A1HSD17B10KDM4EGAAPOLB | |
| SCHEMBL11010262 | 0.75 | KDM4E (0.43) | ALDH1A1KDM4ECA1CA2CA9 | |
| SCHEMBL9910017 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HSD17B10KDM4EGAAPOLB | |
| SCHEMBL9455633 | 0.74 | ALDH1A1 (0.50) | ALDH1A1HSD17B10KDM4ECA1CA2 | |
| SCHEMBL8577595 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HSD17B10KDM4ENPC1GAA | |
| SCHEMBL6805568 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HSD17B10KDM4ECA1CA2 | |
| SCHEMBL10238639 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HSD17B10KDM4ECA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760025-A | ADMINISTERING TESTOSTERONE 5A-REDUCTASE INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 1998-06-02 | — | — | US | claimed |
| US-5760042-A | INHIBITOR OF PHOSPHODIESTERASES | SANKYO COMPANY, LIMITED (JP) | 1998-06-02 | — | — | US | claimed |
| EP-0567271-B1 | Steroid derivatives for the treatment of prostatic hypertrophy, their preparation and uses | SANKYO CO (JP) | 1997-07-02 | — | — | EP | claimed |
| US-5616600-A | Griseolic acid compounds and their use as a phosphodiesterase inhibitor | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | claimed |
| US-5556975-A | CYCLIC GMP PHOSPHODIESTERASE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | claimed |
| US-5536714-A | Steroid derivatives for the treatment of prostatic hypertrophy their preparation and uses | SANKYO COMPANY, LIMITED (JP) | 1996-07-16 | — | — | US | claimed |
| US-5532369-A | NUCLEOTIDE INHIBITORS OF PHOSPHODIESTERASE | SANKYO COMPANY, LIMITED (JP) | 1996-07-02 | — | — | US | claimed |
| EP-0318060-B1 | Griseolic acid derivatives, their preparation and their use | SANKYO CO (JP) | 1995-10-25 | — | — | EP | claimed |
| EP-0319050-B1 | Griseolic acid derivatives, their preparation and their use | SANKYO CO (JP) | 1995-04-12 | — | — | EP | claimed |
| EP-0567966-A1 | Cyclic imino derivatives, medicaments containing these compounds and processes for the production thereof | Dr. Karl Thomae GmbH (DE) | 1993-11-03 | — | — | EP | claimed |
| US-4464366-A | Cephem compounds having a terminal aminocarboxylic acid grouping and containing an azacyclyl(thio)ureido group | CIBA GEIGY CORPORATION (US) | 1984-08-07 | — | — | US | claimed |
| EP-0105459-A2 | Syn-isomer of 7-substituted-3-vinyl-3-cephem compounds, processes for production thereof and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-04-18 | — | — | EP | claimed |
| EP-0089926-A2 | Pharmaceutical preparations of tetracycles containing nitrogen, and compounds of this type | CIBA-GEIGY AG (CH) | 1983-09-28 | — | — | EP | claimed |
| US-4381299-A | 7-Amino-thiadiazole oxyimino derivatives of cephem and cepham compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-26 | — | — | US | claimed |
| US-4323567-A | BACTERICIDES | NARISADA MASAYUKI | 1982-04-06 | — | — | US | claimed |
| EP-0041047-A2 | Dioxide compounds, process for their preparation and their use | CIBA-GEIGY AG (CH) | 1981-12-02 | — | — | EP | claimed |
| EP-0022245-A2 | Aminothiadiazolyl derivatives, process for their preparation, pharmaceutical compositions containing them;starting compounds and process for their preparation | CIBA-GEIGY AG (CH) | 1981-01-14 | — | — | EP | claimed |
| EP-0015240-A1 | Azacyclyl (thio) ureidoacetyl compounds and their preparation | CIBA-GEIGY AG (CH) | 1980-09-03 | — | — | EP | claimed |
| EP-0013762-A2 | Cephem and cepham compounds, processes for their preparation, pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-08-06 | — | — | EP | claimed |
| US-4180571-A | Arylmalonamido-1-oxadethiacephalosporins | SHIONOGI & CO., LTD. (JP) | 1979-12-25 | — | — | US | claimed |