Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.68 |
| ▸ | DHODH | Q02127 | 2/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805514 | 0.90 | PARP1 (0.69) | PARP1DHODHPARP2PLK4MAPK13 | |
| SCHEMBL6811155 | 0.89 | PARP1 (0.71) | PARP1DHODHPARP2PLK4MAPK13 | |
| SCHEMBL18252746 | 0.84 | PARP1 (0.78) | PARP1DHODHPLA2G2AALOX15PTGS2 | |
| SCHEMBL6805582 | 0.83 | PARP1 (0.46) | PARP1CHEK2 | |
| SCHEMBL7480088 | 0.81 | PARP1 (0.44) | PARP1DHODHALOX15 | |
| SCHEMBL6807493 | 0.77 | PARP1 (0.57) | PARP1DHODHPLK4MAPK13DYRK3 | |
| SCHEMBL6805347 | 0.75 | PARP1 (0.63) | PARP1DHODHPLA2G2AALOX15PTGS2 | |
| SCHEMBL29412005 | 0.74 | PARP1 (0.74) | PARP1DHODHPLK4MAPK13DYRK3 | |
| SCHEMBL6590776 | 0.74 | PARP1 (0.46) | PARP1DHODHALOX15CHEK2 | |
| SCHEMBL6591504 | 0.74 | PARP1 (0.49) | PARP1DHODHPLA2G2AALOX15PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |