Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.46 |
| ▸ | DHODH | Q02127 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591504 | 0.91 | PARP1 (0.49) | PARP1DHODHHPSECHEK2ALOX15 | |
| SCHEMBL6805514 | 0.83 | PARP1 (0.69) | PARP1DHODHCHEK2 | |
| SCHEMBL7480088 | 0.83 | PARP1 (0.44) | PARP1DHODHALDH1A1HPSETP53 | |
| SCHEMBL6584288 | 0.81 | PARP1 (0.40) | PARP1ALDH1A1HPSECHEK2TP53 | |
| SCHEMBL6585207 | 0.80 | PARP1 (0.51) | PARP1DHODHALDH1A1HPSECHEK2 | |
| SCHEMBL6586846 | 0.77 | PARP1 (0.46) | PARP1DHODHCHEK2 | |
| SCHEMBL6585381 | 0.77 | CBFB (0.67) | PARP1DHODHALDH1A1TP53CYP3A4 | |
| SCHEMBL6590617 | 0.76 | PARP1 (0.48) | PARP1DHODHHPSECHEK2 | |
| SCHEMBL6590890 | 0.75 | METAP2 (0.50) | PARP1DHODHALDH1A1CHEK2TP53 | |
| SCHEMBL6585540 | 0.75 | CBFB (0.47) | PARP1DHODHALDH1A1HPSECHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |