Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PRKX | P51817 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6807486 | 0.86 | AURKA (0.38) | PLK4DAPK3MAP4K4RETKDR | |
| SCHEMBL6805935 | 0.83 | PARP1 (0.52) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL6804675 | 0.82 | PARP1 (0.36) | PLK4DAPK3MAP4K4RETKDR | |
| SCHEMBL6805212 | 0.79 | PARP1 (0.39) | PLK4DAPK3MAP4K4RETKDR | |
| SCHEMBL6805469 | 0.77 | NPC1 (0.43) | PARP1 | |
| SCHEMBL6807302 | 0.74 | TRPV1 (0.42) | PARP1 | |
| SCHEMBL6806365 | 0.73 | PARP1 (0.54) | PLK4DAPK3MAP4K4RETKDR | |
| SCHEMBL6807466 | 0.72 | ALDH1A1 (0.42) | PLK4DAPK3MAP4K4RETKDR | |
| SCHEMBL6589472 | 0.72 | PKN2 (0.39) | PLK4DAPK3MAP4K4RETKDR | |
| SCHEMBL6807483 | 0.69 | PARP1 (0.53) | PLK4MAP4K4PRKXROCK1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |