Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6799725 | 0.91 | NPC1 (0.49) | HDAC1NPC1RAB9APDE2ASMN1; SMN2 | |
| SCHEMBL14800208 | 0.88 | HPGD (0.53) | HDAC1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6805679 | 0.85 | HDAC1 (0.56) | HDAC1HPGDLMNAGAA | |
| SCHEMBL9126131 | 0.85 | RAB9A (0.57) | HDAC1NPC1RAB9APDE2AHPGD | |
| SCHEMBL14800316 | 0.84 | MEN1 (0.54) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL9038215 | 0.84 | HPGD (0.53) | NPC1RAB9APDE2AHPGDSMN1; SMN2 | |
| SCHEMBL9461934 | 0.82 | HPGD (0.51) | NPC1RAB9AHPGDSMN1; SMN2SIRT2 | |
| SCHEMBL4913399 | 0.81 | NPC1 (0.47) | HDAC1NPC1RAB9APDE2AHPGD | |
| SCHEMBL10354608 | 0.81 | KMT2A (0.59) | NPC1RAB9APDE2AHPGDSMN1; SMN2 | |
| SCHEMBL11567657 | 0.80 | NPC1 (0.53) | NPC1RAB9APDE2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |